ED Medications

Sildenafil, tadalafil, vardenafil and avanafil: how each works, how long it lasts, doses, side effects and brand vs generic.

11 guides

The brief

The four FDA-approved oral ED medications are all PDE5 inhibitors, but they differ in how fast they start, how long they last and how they are priced. These guides cover each one from its FDA label, plus the head-to-head comparisons people actually search for.

Educational information only. Every ED medication is prescription-only, and a licensed provider decides what is appropriate for you.

01

Start here · Explainer

Sildenafil vs. Tadalafil

A factual, side-by-side look at the two most common ED molecules, what they are, how they differ in FDA-approval status and duration, and how to access them legitimately through a licensed provider.

Read it7 min read

  1. 02

    Comparison

    Viagra vs Cialis: Differences, Duration & Which to Choose

    An educational, plain-English comparison of sildenafil and tadalafil, onset, how long each lasts, daily vs as-needed dosing, side effects, food interactions, and what actually drives the cost.

    11 min read
  2. 03

    Explainer

    How Long Does Cialis Last? Half-Life, Timing and Side Effects

    Tadalafil's 36-hour window, its 17.5-hour half-life, how long it stays in your system, the side effects listed on the FDA label, and whether you can take Viagra and Cialis together.

    11 min read
  3. 04

    Explainer

    Vardenafil (Generic Levitra): Dosage, Side Effects and Levitra vs Viagra

    What vardenafil is, how to take it, how long it lasts, its side effects and interactions, how it compares with Viagra and Cialis, and where to get generic vardenafil online, all from the FDA label.

    12 min read
  4. 05

    Explainer

    Sildenafil Dosage Guide: 25 mg vs. 50 mg vs. 100 mg

    What FDA labeling actually says about sildenafil (generic Viagra) doses, the three standard strengths, a typical starting dose, timing before activity, the role of food, and why a licensed prescriber decides your dose, not a website.

    10 min read
  5. 06

    Explainer

    Tadalafil Dosage Guide: Daily (2.5 to 5 mg) vs. As-Needed (5 to 20 mg)

    What each tadalafil strength is for, why it has a 'weekend' reputation, how timing flexibility works, and why your prescriber, not a chart, decides your dose.

    10 min read
  6. 07

    Comparison

    Daily vs As-Needed Tadalafil: Which Dose Is Right?

    Daily low-dose tadalafil (2.5 or 5 mg) versus as-needed tadalafil (usually 10 mg, range 5 to 20 mg): how fast each works, side effects by regimen from the FDA label, the BPH bonus, monthly pill math with real provider prices, and why a clinician makes the call.

    15 min read
  7. 08

    Explainer

    Sildenafil Side Effects: Common, Serious & How to Manage Them

    How often each sildenafil (generic Viagra) side effect happens at 25, 50 and 100 mg according to the FDA label, how long they last, what the blue-vision effect is, the rare warning signs that mean you call a doctor now, and how a prescriber reduces them.

    15 min read
  8. 09

    Explainer

    How Long Does Viagra Take to Work? Timing & What Affects It

    Sildenafil's onset, how food and alcohol delay it, how long the effects last, and a practical way to time a dose.

    9 min read
  9. 10

    Explainer

    ED Meds and Blood Pressure: What's Safe and What Isn't

    The one combination you must never make, how much each ED pill actually lowers blood pressure in label studies, which blood-pressure drugs need extra care, the heart conditions that change the answer, and what to do if pills are off the table.

    16 min read
  10. 11

    Buyer's Guide

    Generic Cialis Online: Where to Get Tadalafil Legally in 2026

    Generic Cialis (tadalafil) is often one of the less expensive prescriptions in men's health, and you can get it online legally after a short consultation with a licensed clinician. Here is how the online route works, what it costs at each provider we track, and how to tell an FDA-approved generic from a compounded one.

    8 min read

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